At this point I sit down at the computer and write the home page.
First impressions in web design, like so many things, is critical. Now is when your message get's delivered, and when most users scope out navigation and the end game. Normally the home page is the first page people see so getting it right is critical. Don't waste your chances.
Likewise, don't waste anyone's time. Make sites that load quickly. From the instant someone clicks a link to the moment they decide to stay is at most a few seconds. It only takes a fraction of a second to hit the back button.
As I said before, there is no "best" way to make a site. Be creative. Get in the habit of looking at the source code of sites you like and use it for ideas and inspiration. That said, this is the fun part of web design and it's easy to get off on a tangent. Cool as something may be, if it's just window dressing, it shouldn't be there.
Once my home page is made, I use it as a template for the rest of the site. The header, nav and footer sections stay pretty much the same throughout. Essentially, the only thing that changes on other pages is the contents of the article section and a few heading elements.